The UMD Predictor Pro system was specifically designed to handle small to large NGS datasets including WES/WGS. To do so, it precomputed the impact of SNPS from coding genes and stored results in the UMD Predictor Pro database.
The user can access mutations either one-by-one or by a handful through the website of by directly submitting a VCF file through an API. The result is provided as an annotated VCF format that contains the UMD Predictor Pro value of each mutation in order to be implemented in any local pipeline. Depending on the server load, the speed can reach 100,000 mutations/s.